Effects of Photodynamic Bio-stimulation on Inflammatory Phase in Healing Process.

چکیده مقاله

Therapeutic benefits of Photodynamic Therapy in treatment of wounds have been reported since 1960s .However ,many of the relevant results described inconsistency ,mainly due to methodology bias or lack of standard method in different studies .Beyond ,the application of some of the light sources as a therapeutic modality is still controversial ,especially when it comes to apply the modality in initial stages of tissue repair. Clinical practice with photodynamic therapy ,especially low or high level laser therapies ,helps the researchers to identify benefits of these modern care strategies .However ,the questions on biological causes and mechanisms are still arising .The initial effects of laser biostimulation on an injured tissue cause to release some preforming substances such as histamine ,serotonin ,bradykinin . Simultaneously ,Laser application may modify normal enzymatic reactions ,accelerate or delay some of the biological chains and promote ATP production .Inflammation ,as the first stage of repair ,is essential to preserve the integrity of the organism and involves a homodynamic interaction between inflammatory and vascular cells .Laser application has shown to be an anti-inflammatory alternative with similar effects with the NSAIDs lead to inhibit PGE ,3COX and histamine .As a result ,laser application seems to be able to modulate inflammation for different tissues .This presentation aims to explain anti-inflammatory effects of low and high level lasers and provide some clinical examples that demonstrate tissue healing process in initial phases under photodynamic therapy.