| نویسندگان | Ghobadi Dana V - Arshi S - Shokouhi Shoormasti R - Fateh M - Nabavi M - Bemanian MH - Fallahpou M - Torabzadeh M - Aghapour SA - Zaker Z. |
|---|---|
| نشریه | Journal of Allergy and Clinical Immunology |
| نوع مقاله | Full Paper |
| تاریخ انتشار | 2019 |
| رتبه نشریه | ISI |
| نوع نشریه | چاپی |
| کشور محل چاپ | ایران |
چکیده مقاله
Rationale
Oral immunotherapy (OIT) is considered as a treatment protocol for desensitization to food allergens. The aim of this study was to evaluate the effect of OIT for egg white in patients with IgE-mediated hypersensitivity to egg white.
Methods
This clinical trial was conducted from February to August 2018 in Rasool Akram Hospital, Tehran, Iran. The patients with a history of allergic reaction and positive skin prick test (SPT) to egg white as well as the inability to pass the Oral Food Challenge (OFC) were selected. Eight patients underwent OIT for egg white during 6 months while controls avoided to consume egg white. The SPT, the assessment of specific IgE and IgG4 were performed before and after OIT.
Results
After 6 months OIT, all patients of OIT group were able to tolerate 40 cc pasteurized raw egg white while none of the control group was able to pass the challenge. A significant difference in wheal size to egg white was found before and after OIT in OIT group (P=0.01) as well as in comparison with control group (P=0.02). The results revealed significant decrease in specific IgE to egg white (P=0.01) as well as increase of specific IgG4 to egg white although insignificantly. Moreover, IgE/IgG4 ratio to egg white was 0.44 versus 0.12 (P=0.01).
Conclusions
Since all patients in OIT group continued 6 months follow up and nobody left the study due to side effects of therapeutic process, this method could be considered as a promising and safe method to treat food allergies.