Surgical Margin Status and Local Recurrence in Breast-Conserving Surgery

چکیده مقاله

Abstract

Background: Breast-conserving surgery (BCS) followed by radiotherapy is the standard treatment for early stages of breast cancer. Margin status may significantly impact local recurrence (LR) in patients treated with BCS. In this study, we evaluated the relationship between margin status and local recurrence.

Material and Methods:

In a retrospective cross-sectional study, we analyzed medical records of 1,716 breast cancer patients treated by BCS in Motamed Cancer Institute (MCI) from 2001 to 2020. The collected data included pathology report data such as tumor size, axillary involvement, molecular subtype, margin status, histological grade, lymphovascular invasion, and LR and demographic characteristics. Margins were defined as close if surgical margins were less than 2 mm; as free if surgical margins were more than 2 mm, and as positive if malignant cells were present in one of the tissue edges.

Results:

In total, we found that 133 (7.7%) patients had local recurrence. The mean follow-up time was 46.79 (± 34.47) months. The multivariate logistic regression analysis showed the presence of involved margins (OR= 9.27; 95% CI: 2.08-41.36) and stage III of cancer (OR=6.69; 95% CI: 1.95-22.95) were correlated with local recurrence.

Conclusions:

The results of this study showed a low LR rate for breast cancer. Margin involvement and stage III breast cancer were correlated with high LR risk and should be considered for these patients before surgery to reduce the LR  rate. Prospective trials and long-term follow-up are required to confirm these results.

Keywords: Breast cancer, Local recurrence, Margin