| EN عنوان مقاله | Natural psychedelics in the treatment of depression; a review focusing on neurotransmitters |
|---|---|
| نویسندگان | Samane Jahanabadi, Shayan Amiri, Mehdi Karkeh-Abadi, Ali Razmi |
| نشریه | Elsevier |
| نوع مقاله | Full Paper |
| تاریخ انتشار | September 2023 |
| رتبه نشریه | ISI |
| نوع نشریه | چاپی |
| کشور محل چاپ | هلند |
چکیده مقاله
Natural psychedelic compounds are emerging as potential novel therapeutics in psychiatry. This review will discuss how natural psychedelics exert their neurobiological therapeutic effects, and how different neurotransmission systems mediate the effects of these compounds. Further, current therapeutic strategies for depression, and novel mechanism of action of natural psychedelics in the treatment of depression will be discussed. In this review, our focus will be on N, N-dimethyltryptamine (DMT), reversible type A monoamine oxidase inhibitors, mescaline-containing cacti, psilocybin/psilocin-containing mushrooms, ibogaine, muscimol extracted from Amanita spp. mushrooms and ibotenic acid.