| نویسندگان | Hamid Reza Bidkhori, Ahmad Reza Bahrami, Moein Farshchian, Hojjat Naderi Meshkin, Asieh Heirani Tabasi, Mahdi Mirahmadi, Mina Shahriyari, Naghmeh Ahmadiankia, Armin Attaran, Mahmood Raeesolmohaddeseen, Hadi Bakhtiari, Maryam Moghaddam Matin |
|---|---|
| همایش | International Congress on Stem Cells and Regenerative Medicine |
| تاریخ برگزاری همایش | 2015-05-20 |
| نوع ارائه | سخنرانی |
| سطح همایش | داخلی |
چکیده مقاله
Recent studies have demonstrated that adipose-derived mesenchymal stem cells (MSCs) can attenuate ischemic tissue injury, possibly by their paracrine effect or differentiation into local cell types. But homing of transplanted cells either transfused systematically or via direct intra-lesional injection, is reported to be very low and transient, which reduces the therapeutic effects. CXCR4 is identified as crucial for homing and engraftment of stem cells. In this study, we overexpressed CXCR4 on Adipose-derive MSC to enhance their level of engraftment and perhaps improve their translational effectiveness.