| نویسندگان | Asieh Heirani-Tabasi, Hojjat Naderi-Meshkin, Maryam M Matin, Mahdi Mirahmadi, Mina Shahriyari, Naghmeh Ahmadiankia, Nasser Sanjar Moussavi, Hamid Reza Bidkhori, Mahmood Raeesolmohaddeseen, Ahmad Reza Bahrami |
|---|---|
| نشریه | Cell Adhesion & Migration |
| شماره صفحات | 118-126 |
| نوع مقاله | Full Paper |
| تاریخ انتشار | 2018-03-04 |
| رتبه نشریه | ISI |
| نوع نشریه | چاپی |
| کشور محل چاپ | ایران |
چکیده مقاله
Use of mesenchymal stem cells (MSCs) has been introduced as a promising tool, for structural and functional recovery of damaged tissues/organs. Studies have indicated that interactions between chemokine receptors and their ligands have a critical role in homing of MSCs to the site of injury. Although CXCR4 variants have been characterized, the exact role of each transcript in homing has remained unclear. In this study, cells were pretreated with various hypoxia-mimicking compounds (valproic acid, cobalt-chloride, and deferoxamine mesylate). Results indicated that both variants of CXCR4 were overexpressed after 24 hours of treatments and their expression could cooperatively induce and promote the cell migration. Moreover, deferoxamine mesylate was more effective in overexpression of variant A (lo), which resulted in higher level of CXCR4 protein and the highest rate of migration of the cells. In conclusion …