| نویسندگان | Mohammad Hossein Derakhshan Nazari, Rana Askari Dastjerdi, Parnian Ghaedi Talkhouncheh, Ahmad Bereimipour, Hamidreza Mollasalehi, Amir Ali Mahshad, Ali Razi, Mohammad Hossein Nazari, Amin Ebrahimi Sadrabadi, Sara Taleahmad |
|---|---|
| نشریه | Cell Journal (Yakhteh) |
| شماره صفحات | 302 |
| ضریب تاثیر (IF) | 2.2 |
| نوع مقاله | Original Research |
| تاریخ انتشار | 2022/6 |
| رتبه نشریه | ISI |
| نوع نشریه | الکترونیکی |
| کشور محل چاپ | ایران |
چکیده مقاله
Objectives
Non-small cell lung adenocarcinoma (NSCLC) is the most common type of lung cancer, which is considered as the most lethal and prevalent cancer worldwide. Recently, molecular changes have been implicated to play a significant role in the cancer progression. Despite of numerous studies, the molecular mechanism of NSCLC pathogenesis in each sub-stage remains unclear. Studying these molecular alterations gives us a chance to design successful therapeutic plans which is aimed in this research.
Materials and Methods
In this bioinformatics study, we compared the expression profile of 7 minor stages of NSCLC adenocarcinoma, including GSE41271, GSE42127, and GSE75037, to clarify the relation of molecular alterations and tumorigenesis. At first, 99 common differentially expressed genes (DEG) were obtained. Then, functional enrichment analysis and protein-protein interaction (PPI) network construction were performed to uncover the association of significant cellular and molecular changes. Finally, gene expression profile interactive analysis (GEPIA) was employed to validate the results by RNA-seq expression data.